The purpose of the Center for Health, Work & Environment (CHWE) Center of Excellence in Total Worker Health (TWH) is to advance the overall safety, health, and well-being of workers through transdisciplinary research, effective interventions, outreach and communications, education/training, and rigorous evaluation that inform improvements in all of the above. CHWE addresses the need for research on Total Worker Health intervention strategies, focusing on the large number of workers and workplaces at highest risk of occupational fatality, injury, and illness. Specifically, CHWE research will build on the team?s experience in creating innovative TWH interventions and practical outreach tools for small businesses, the education industry, and other high-risk sectors such as agriculture.